(1E,4E)-1,5-Bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one
نویسندگان
چکیده
There are two crystallograpically independent mol-ecules in the asymmetric unit of the title bis-chalcone derivative, C25H32N2O. Both mol-ecules are twisted with a dihedral angle between the two substituted benzene rings of 11.19 (16)° in one mol-ecule and 14.40 (15)° in the other. The central penta-1,4-dien-3-one fragments make dihedral angles of 8.49 (17) and 4.26 (17)° with the two adjacent benzene rings in one mol-ecule, whereas the corresponding values are 8.42 (16) and 6.18 (16)° in the other. In the crystal, mol-ecules are arranged into chains along the c-axis direction. Adjacent chains are inter-linked by weak inter-molecular C-H⋯O inter-actions. The crystal is further stabilized by C-H⋯π inter-actions.
منابع مشابه
(1E,4E)-1,5-Bis(2,4-dimethylphenyl)penta-1,4-dien-3-one
In the title compound, C(21)H(22)O, a derivative of the biologically active compound curcumin, the dihedral angle between the aromatic ring planes is 20.57 (11)°.
متن کاملEffects of (1E,4E)-2-Methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one on Trypanosoma cruzi and Its Combinational Effect with Benznidazole, Ketoconazole, or Fluconazole
This study reports the activity induced by (1E,4E)-2-methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one (A3K2A3) against Trypanosoma cruzi. This compound showed trypanocidal activity against the multiplicative epimastigote and amastigote forms of this protozoan, with IC50 values of 1.99 ± 0.17 and 1.20 ± 0.16 μM, respectively, and EC50 value of 15.57 ± 0.34 μM against trypomastigotes. The combin...
متن کامل(1E,4E)-1,5-Bis[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one
In the title compound, C(19)H(12)F(6)O, a monoketone derivative of curcumin, both double bonds have a trans conformation. The mol-ecule is mostly planar with all C and O atoms essentially coplanar, with the exception of one benzene ring, which is tilted by 17.18 (1)° with respect to the plane of the remainder of the mol-ecule. The r.m.s. deviation from planarity of the coplanar section is 0.009...
متن کاملBase-Promoted Cyclocondensation of (1E,4E)-1,5-Diarylpenta-1,4-dien-3-ones with Guanidine Hydrochloride: Facile Synthesis of E-2-Amino-4-Aryl-6-(2-Arylethenyl)Pyrimidines
Submit Manuscript | http://medcraveonline.com classes of pyrimidines. The pharmaceutical importance of these compounds lies on the fact that they can be effectively used as analgesics, anti-inflammatory, anticonvulsant, insecticidal, herbicidal, antitubercular, anticancer and antidiabetic agents [4-6]. Also, the pyrimidine and aminopyrimidine structures are frequently-occurring motifs in commer...
متن کامل(1E,4E)-1,5-Bis(4-methylphenyl)penta-1,4-dien-3-one
The title compound, C(19)H(18)O, crystallizes in a non-centrosymmetric space group although the mol-ecule has no chiral centre. The dihedral angle between the aromatic rings is 20.43 (13)°. The structure is stabilized by two intra-molecular hydrogen bonds, and by four π-π and three C-H⋯π inter-actions between the aromatic rings. The perpendicular distances between the centroids of the rings inv...
متن کامل